Stimulation of anterior pituitary adenyl cyclase activity and adenosine 3':5'-cyclic phosphate by hypothalamic extract and prostaglandin E1.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 63 ·No. 3 ·1969-07-00 ·Pages 918-25

Zor U, Kaneko T, Schneider HP, McCann SM, Lowe IP, Bloom G, Borland B, Field JB

Abstract

Hypothalamic extract, containing the releasing factors for anterior pituitary hormones, within minutes stimulated adenyl cyclase activity and adenosine 3':5'-cyclic phosphate (cyAMP) concentrations in rat anterior pituitary in vitro. Cerebral cortical extract was ineffective and hypothalamic extract had no effect on these parameters in posterior pituitary or thyroid. Prostaglandin E(1) also increased adenyl cyclase activity and cyAMP levels in anterior pituitary tissue. Although NaF augmented adenyl cyclase activity, it did not elevate cyAMP. Epinephrine, norepinephrine, histamine, serotonin, dopamine, and vasopressin did not increase either adenyl cyclase or cyAMP. The increased adenyl cyclase and cyAMP produced by hypothalamic extract was associated with greater luteinizing hormone release from anterior pituitary in vitro.

MeSH Terms

Adenylyl Cyclases Animals Cyclic AMP In Vitro Techniques Pituitary Gland/enzymology Pituitary Hormone-Releasing Hormones Prostaglandins/pharmacology Rats Tissue Extracts/pharmacology

Chemicals

Pituitary Hormone-Releasing Hormones Prostaglandins Tissue Extracts Cyclic AMP Adenylyl Cyclases

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Zor U

Kaneko T

Schneider H P

McCann S M

Lowe I P

Bloom G

Borland B

Field J B

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25 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.63.3.918

Published

1969-07-00

Pages

918-25

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC223540

Subset

External Links

PubMed source DOI: 10.1073/pnas.63.3.918 PMC Full Text View journal details

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Stimulation of anterior pituitary adenyl cyclase activity and adenosine 3':5'-cyclic phosphate by hypothalamic extract and prostaglandin E1.

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