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PMID: 4313195 Published · ppublish English Journal Article

Trans-species rescue of defective genomes of murine sarcoma virus from hamster tumor cells with helper feline leukemia virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 65 ·No. 1 ·1970-01-00 ·Pages 81-7

Sarma PS, Log T, Huebner RJ

Abstract

This report describes a trans-species rescue of defective MSV genome with helper leukemia virus derived from cats. This rescue was achieved by in vitro co-cultivation of hamster tumor cells with feline embryo cells in the presence of helper feline leukemia virus (FeLV), or by inoculation of tumor cells into FeLV-infected newborn cats. The rescued focus-forming viruses produced foci in feline embryo cultures but not in cultures of mouse, rat, and hamster species. One isolate was tested and found to induce sarcoma in a kitten. Antigenic and viral interference studies indicated that the focus-forming virus has the viral envelope of FeLV. Virus stocks consisted of a mixture of focus-forming particles and a 1000-fold excess of helper FeLV. Virus assay pattern in feline embryo cultures with or without added helper FeLV indicated that this helper virus is required for the transformation of feline cells.

MeSH Terms
Animals Animals, Newborn Cats Cricetinae Culture Techniques Defective Viruses Embryo, Mammalian/cytology Helper Viruses Leukemia Virus, Murine Lymphoma, Non-Hodgkin/microbiology Mice Moloney murine leukemia virus Neutralization Tests Rats Sarcoma, Experimental/microbiology Species Specificity Viral Interference
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sarma P S
Log T
Huebner R J
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28 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.65.1.81
Published
1970-01-00
Pages
81-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286194
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.65.1.81 PMC Full Text View journal details
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