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PMID: 4316236 Published · ppublish English Journal Article

Characterization of the strain of adenovirus type 7 carrying the defective monkey cell-adapting component.

Journal of virology ·Vol. 1 ·No. 5 ·1967-10-00 ·Pages 876-82

Butel JS

Abstract

The strain of adenovirus type 7 carrying the defective monkey cell-adapting component (MAC) has been further characterized. MAC is more sensitive to inactivation by ultraviolet light than the associated adenovirus, which, in turn, is more rapidly inactivated than complete simian virus 40 (SV40). The 37% dose was 16 sec for MAC, 60 sec for adenovirus, and 84 sec for SV40. Filtration through membranes revealed that both MAC and adenovirus were retained by 100-mmu filters. MAC equilibrated in cesium chloride at the same buoyant density as the complete adenovirions (1.34 g/ml). Deoxyribonucleic acid extracted from green monkey kidney cells infected with MAC-adenovirus 7 did not hybridize in vitro with SV40 complementary ribonucleic acid. The two components (MAC and adenovirus) of the virus population possess such similar biophysical properties that their separation has not yet been achieved. Evidence to date indicates that MAC is probably not derived from SV40.

MeSH Terms
Adenoviridae/classification,radiation effects Animals Centrifugation, Density Gradient Culture Techniques Cytopathogenic Effect, Viral DNA, Viral/metabolism Defective Viruses Haplorhini Helper Viruses Humans Hybridization, Genetic Kidney Simian virus 40/radiation effects Ultraviolet Rays Virus Replication
Chemicals
DNA, Viral
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Butel J S
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30 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.1.5.876-882.1967
Published
1967-10-00
Pages
876-82
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC375364
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.1.5.876-882.1967 PMC Full Text View journal details
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