Enhancement by poly-D-lysine of poly I: C-induced interferon production in mice.

Applied microbiology ·Vol. 19 ·No. 5 ·1970-05-00 ·Pages 867-9

Rice JM, Turner W, Chirigos MA, Rice NR

Abstract

Poly-d-lysine of high molecular weight enhances interferon induction in mice by the double-stranded complex of polyinosinic and polycytidylic acids and is superior to diethylaminoethyl-dextran in this respect.

MeSH Terms

Animals Culture Techniques Cytopathogenic Effect, Viral Cytosine Nucleotides/pharmacology Dextrans/pharmacology Drug Synergism Ethylamines/pharmacology Female Injections, Intraperitoneal Interferons/biosynthesis L Cells Lysine/pharmacology Mice Molecular Weight Nucleosides/pharmacology Stereoisomerism Stimulation, Chemical Vesicular stomatitis Indiana virus

Chemicals

Cytosine Nucleotides Dextrans Ethylamines Nucleosides Interferons Lysine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Rice J M

Turner W

Chirigos M A

Rice N R

References (6)

6 references, click to expand

Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.
Proc Natl Acad Sci U S A. 1967 Sep;58(3):1004-10 PMID: 5233831
Effect of DEAE-dextran on interferon production and protective effect in mice treated with the double-stranded polynucleotide complex polyinosinic-polycytidylic acid.
J Immunol. 1969 Jan;102(1):24-7 PMID: 5765457
Requirement of a stable secondary structure for the antiviral activity of polynucleotides.
Nature. 1969 Jun 21;222(5199):1148-52 PMID: 4307027
Effective antiviral therapy of two murine leukemias with an interferon-inducing synthetic carboxylate copolymer.
Int J Cancer. 1969 May 15;4(3):267-78 PMID: 5801414
The specificity of interferon induction in chick embryo cells by helical RNA.
Proc Natl Acad Sci U S A. 1969 May;63(1):160-7 PMID: 5257961
Influence of polyamines on induction of interferon and resistance to viruses by synthetic polynucleotides.
Proc Soc Exp Biol Med. 1969 Oct;132(1):212-8 PMID: 4310173

Article Info

Journal

Applied microbiology

Abbr.

Appl Microbiol

ISSN

0003-6919

DOI

10.1128/am.19.5.867-869.1970

Published

1970-05-00

Pages

867-9

Language

English

Region

United States

NLM ID

7605802

PMCID

PMC376805

Subset

External Links

PubMed source DOI: 10.1128/am.19.5.867-869.1970 PMC Full Text

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Enhancement by poly-D-lysine of poly I: C-induced interferon production in mice.

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