Tilorone hydrochloride: an orally active antiviral agent.

Science (New York, N.Y.) ·Vol. 169 ·No. 3951 ·1970-09-18 ·Pages 1213-4

Krueger RE, Mayer GD

Abstract

Tilorone hydrochloride, 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one dihydrochloride, given orally to mice before they are infected is active against at least nine viruses of both RNA and DNA groups. The compound is effective when given prophylactically; the optimum time of treatment depends on the route of infection.

MeSH Terms

Administration, Oral Animals Antiviral Agents/administration & dosage,therapeutic use Encephalitis/drug therapy Encephalomyocarditis virus/drug effects Fluorenes/therapeutic use Herpes Simplex/drug therapy Mice Myocarditis/drug therapy Orthomyxoviridae Infections/drug therapy Semliki forest virus/drug effects Vesicular stomatitis Indiana virus/drug effects Virus Diseases/drug therapy

Chemicals

Antiviral Agents Fluorenes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Krueger R E

Mayer G D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.169.3951.1213

Published

1970-09-18

Pages

1213-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.169.3951.1213 View journal details

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