Site II-specific inhibition of mitochondria oxidative phosphorylation by trehalose-6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis.

Adenosine Triphosphatases/metabolism Animals Antimycin A/pharmacology Ascorbic Acid/metabolism Carbon Isotopes Chickens Dinitrophenols/pharmacology Disaccharides/metabolism Fatty Acids/metabolism Female Ferricyanides/metabolism Glucosamine/pharmacology Glutamates/metabolism Glycolipids/pharmacology Glycosides/pharmacology Guinea Pigs Hydroxybutyrates/metabolism Ketoglutaric Acids/metabolism Malates/metabolism Male Malonates/metabolism Mice Mitochondria, Liver/metabolism Mycobacterium tuberculosis NAD/metabolism Oxidative Phosphorylation/drug effects Pyruvates/metabolism Rabbits Rats Species Specificity Stimulation, Chemical Succinates/metabolism Sulfites/pharmacology

Carbon Isotopes Dinitrophenols Disaccharides Fatty Acids Ferricyanides Glutamates Glycolipids Glycosides Hydroxybutyrates Ketoglutaric Acids Malates Malonates Pyruvates Succinates Sulfites NAD Antimycin A Adenosine Triphosphatases Glucosamine Ascorbic Acid