Adenyl cyclase as a link between photon capture and changes in membrane permeability of frog photoreceptors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 3 ·1971-03-00 ·Pages 561-2

Bitensky MW, Gorman RE, Miller WH

Abstract

Tomita has shown by electrophysiological measurements that the photoreceptors of the vertebrate retina are depolarized (excited) by darkness and hyperpolarized (inhibited) by light. Excitation is accompanied by an increase, and inhibition by a decrease, in the sodiumion permeability of the receptor cell. The retinal-rod outer segments of the frog contain an adenyl cyclase that is active in darkness and inactivated by light. This cyclase has a specific activity ten-times higher than the activity in previously described tissues. It is suggested that cyclic AMP is an intermediate in the light- and dark-induced changes in sodium permeability in the photoreceptor cell.

MeSH Terms

Adenine Nucleotides/metabolism Adenylyl Cyclases/metabolism Animals Biological Transport, Active Cell Membrane Permeability Cyclic AMP/metabolism Dark Adaptation

Chemicals

Adenine Nucleotides Cyclic AMP Adenylyl Cyclases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bitensky M W

Gorman R E

Miller W H

References (10)

10 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.3.561

Published

1971-03-00

Pages

561-2

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388988

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.3.561 PMC Full Text View journal details

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Adenyl cyclase as a link between photon capture and changes in membrane permeability of frog photoreceptors.

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