Further studies on the relationship of the stimulatory effects of phenobarbital and 3,4-benzpyrene on hepatic heme synthesis to their effects on hepatic microsomal drug oxidations.

Animals Benzopyrenes/pharmacology Carbon Isotopes Cytochromes/analysis,metabolism Enzyme Activation Heme/analysis,biosynthesis Levulinic Acids Ligases/metabolism Liver/analysis,metabolism Male Microsomes, Liver/analysis,drug effects,enzymology,metabolism NAD Oxidation-Reduction Oxidoreductases/metabolism Phenobarbital/pharmacology Proteins/analysis Rats Stimulation, Chemical

Benzopyrenes Carbon Isotopes Cytochromes Levulinic Acids Proteins NAD Heme Oxidoreductases Ligases Phenobarbital