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PMID: 4323933 Published · ppublish English Journal Article

Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog.

The Journal of physiology ·Vol. 213 ·No. 3 ·1971-03-00 ·Pages 545-56

Kuno M, Turkanis SA, Weakly JN

Abstract

1. End-plate potentials were recorded intracellularly at the frog neuromuscular junction bathed in a solution containing a low concentration of calcium and a high concentration of magnesium.2. The muscle was subsequently subjected to ;cholinesterase staining', and the area of the individual end-plates, studied with intracellular electrodes, was measured.3. A positive correlation was found between the end-plate area and the diameter of muscle fibres.4. The mean quantum content (m) showed a positive correlation with the size of end-plates.5. The frequency of spontaneous miniature end-plate potentials was positively correlated with m as well as with end-plate area.6. It is concluded that the amount of transmitter released following nerve stimulation is related to the size of nerve endings.

MeSH Terms
Animals Anura Calcium/pharmacology Cholinesterases Electric Stimulation Electrophysiology In Vitro Techniques Magnesium/pharmacology Membrane Potentials Myofibrils/physiology Nerve Endings/anatomy & histology Neuromuscular Junction/physiology Synaptic Transmission
Chemicals
Cholinesterases Magnesium Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kuno M
Turkanis S A
Weakly J N
References (26)
26 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1971.sp009399
Published
1971-03-00
Pages
545-56
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1331740
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1971.sp009399 PMC Full Text View journal details
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