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PMID: 4324594 Published · ppublish English Journal Article

Effects of adrenaline on nerve terminals in the superior cervical ganglion of the rabbit.

British journal of pharmacology ·Vol. 41 ·No. 2 ·1971-02-00 ·Pages 331-8

Christ DD, Nishi S

Abstract

1. Adrenaline decreases the release of transmitter from the presynaptic nerves in the superior cervical ganglion of the rabbit. The presynaptic mechanism of adrenaline action was investigated with micro-electrode techniques.2. Adrenaline (10(-5)M) did not change the threshold of the presynaptic nerve terminals to a current stimulus.3. The effect of adrenaline on the excitatory postsynaptic potential (e.p.s.p.) was decreased when the calcium concentration of the perfusing solution was increased to 10 mM.4. The effect of adrenaline on a train of e.p.s.ps (30-50 Hz) was analysed. Adrenaline decreased the readily available stores of transmitter, but only slightly changed the probability of release.5. The probability of release was increased when the calcium concentration was increased to 5 mM.6. It was concluded that adrenaline acts directly on excitation release coupling in the presynaptic terminals.

MeSH Terms
Animals Caffeine/pharmacology Calcium/pharmacology Electric Stimulation Epinephrine/pharmacology Ganglia, Autonomic/drug effects In Vitro Techniques Membrane Potentials/drug effects Neck Nerve Endings/drug effects Rabbits Receptors, Drug Receptors, Neurotransmitter/drug effects Synapses/drug effects Synaptic Transmission/drug effects
Chemicals
Receptors, Drug Receptors, Neurotransmitter Caffeine Calcium Epinephrine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Christ D D
Nishi S
References (24)
24 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1971.tb08033.x
Published
1971-02-00
Pages
331-8
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1703303
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1971.tb08033.x PMC Full Text View journal details
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