Effect of inactivation by hydroxylamine on early functions of poliovirus.

Journal of virology ·Vol. 8 ·No. 1 ·1971-07-00 ·Pages 1-6

Borgert K, Koschel K, Täuber H, Wecker E

Abstract

Evidence is presented that poliovirus particles with a single lethal hit by hydroxylamine do not induce in host cells either inhibition of cellular protein synthesis or viral ribonucleic acid (RNA) replication. The RNA of these viruses is not replicated even if the cells are simultaneously infected with both active and inactivated viruses. The damaged viral RNA seems to have lost both its template function and its function in the translation of normal viral proteins.

MeSH Terms

Amino Acids/metabolism Carbon Isotopes Centrifugation, Zonal Cycloheximide/pharmacology Genetics, Microbial HeLa Cells Hydroxylamines/pharmacology Poliovirus/drug effects,growth & development,metabolism,pathogenicity Protein Biosynthesis RNA, Viral/biosynthesis,isolation & purification,pharmacology Sucrose Templates, Genetic Time Factors Uridine/metabolism Virus Replication

Chemicals

Amino Acids Carbon Isotopes Hydroxylamines RNA, Viral Sucrose Cycloheximide Uridine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Borgert K

Koschel K

Täuber H

Wecker E

References (27)

27 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.8.1.1-6.1971

Published

1971-07-00

Pages

1-6

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC356207

Subset

External Links

PubMed source DOI: 10.1128/JVI.8.1.1-6.1971 PMC Full Text View journal details

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Effect of inactivation by hydroxylamine on early functions of poliovirus.

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