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PMID: 4328416 Published · ppublish English Journal Article

Mechanism of oncogenic transformation by Rous sarcoma virus. II. Effect of rifampin on Rous sarcoma virus infection.

Journal of virology ·Vol. 8 ·No. 1 ·1971-07-00 ·Pages 62-5

Richert NJ, Balduzzi P

Abstract

Rifampin partially inhibits focus formation and virus production in chick embryo fibroblasts infected with Bryan high-titer Rous sarcoma (RAV-1) virus. This inhibition occurs with exposure to rifampin during a critical period between day 1 and day 2 after infection. This suggests that the drug does not affect formation of the provirus or its transcription or translation after the "fixation" step, but it seems to affect one or more events which take place before fixation and activation of virus production.

MeSH Terms
Animals Avian Sarcoma Viruses/drug effects,growth & development,pathogenicity Cell Transformation, Neoplastic Chick Embryo Culture Media Culture Techniques DNA/biosynthesis Fibroblasts Genetic Code Genetics, Microbial Immune Sera Rifampin/pharmacology Time Factors Virus Replication
Chemicals
Culture Media Immune Sera DNA Rifampin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Richert N J
Balduzzi P
References (12)
12 references, click to expand
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    J Natl Cancer Inst. 1971 Apr;46(4):785-8 PMID: 4324813
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.8.1.62-65.1971
Published
1971-07-00
Pages
62-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC356214
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.8.1.62-65.1971 PMC Full Text View journal details
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