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PMID: 4330149 Published · ppublish English Journal Article

Accumulation of untranslated lactose-specific messenger ribonucleic acid during catabolite repression in Escherichia coli.

The Biochemical journal ·Vol. 122 ·No. 2 ·1971-04-00 ·Pages 219-24

Aboud M, Burger M

Abstract

When Escherichia coli K-12 Hfr.H was induced to synthesize beta-galactosidase in the presence of glucose, an untranslated lactose-specific mRNA (lac-mRNA), protected from decay, was found to accumulate progressively within the cells. The lac-mRNA accumulation was unaffected by the carbon source on which the cells had been grown before the induction. The amount of the lac-mRNA available for translation was affected by catabolite repression and 3':5'-cyclic AMP, but it remained unclear whether this was a direct effect on the formation of the lac-mRNA or a consequence of the effect on its translation.

MeSH Terms
Acridines/pharmacology Cyclic AMP/pharmacology Enzyme Induction Enzyme Repression Escherichia coli/metabolism Galactosidases/biosynthesis,metabolism Glucose/metabolism Glycerol/metabolism Leucine/metabolism RNA, Messenger/biosynthesis,metabolism Uridine/metabolism
Chemicals
Acridines RNA, Messenger Cyclic AMP Galactosidases Leucine Glucose Glycerol Uridine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Aboud M
Burger M
References (31)
31 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1220219
Published
1971-04-00
Pages
219-24
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1176765
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1220219 PMC Full Text View journal details
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