Histidine regulation in Salmonella typhimurium. 8. Mutations of the hisT gene.

Journal of bacteriology ·Vol. 108 ·No. 1 ·1971-10-00 ·Pages 410-4

Chang GW, Roth JR, Ames BN

Abstract

The hisT gene, one of six genes in which mutation causes derepression of the histidine operon in Salmonella typhimurium, is shown to code for a protein that is not essential for the growth of the bacteria. This is indicated by the characterization of particular classes of mutations in the hisT gene: amber mutations, frame-shift mutations, and temperature-sensitive mutations that affect repression but not growth. In addition, the class of semilethal mutations was selected for but not found.

MeSH Terms

Alanine Bacterial Proteins Chromosome Mapping Culture Media Enzyme Repression Genes, Regulator Genetics, Microbial Histidine/biosynthesis Mutagens Mutation Phosphoric Monoester Hydrolases/metabolism Quinacrine Salmonella Phages Salmonella typhimurium/drug effects,enzymology,growth & development,metabolism Suppression, Genetic Temperature Transduction, Genetic Triazoles

Chemicals

Bacterial Proteins Culture Media Mutagens Triazoles Histidine Phosphoric Monoester Hydrolases Quinacrine Alanine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Chang G W

Roth J R

Ames B N

References (13)

13 references, click to expand

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.108.1.410-414.1971

Published

1971-10-00

Pages

410-4

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC247079

Subset

External Links

PubMed source DOI: 10.1128/jb.108.1.410-414.1971 PMC Full Text View journal details

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Histidine regulation in Salmonella typhimurium. 8. Mutations of the hisT gene.

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