A possible role of phospholipid in nerve excitation.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 67 ·No. 2 ·1970-10-00 ·Pages 916-20

Wang JH

Abstract

A possible role of phospholipid in regulating the ionic permeability of excitable membranes is proposed. It is assumed that each excitable transport channel in the nerve fiber is lined with two chains of phospholipid dipoles in either parallel or antiparallel directions; a molecular mechanism of nerve excitation is developed that is qualitatively consistent with most of the relevant observations reported in the literature.

MeSH Terms

Acetylcholine/physiology Acetylcholinesterase/metabolism Action Potentials Calcium/metabolism Cell Membrane Permeability Electrophysiology Macromolecular Substances Models, Biological Neural Conduction Phosphatidylcholines/physiology Phosphatidylethanolamines/physiology Sodium/metabolism Synaptic Transmission

Chemicals

Macromolecular Substances Phosphatidylcholines Phosphatidylethanolamines Sodium Acetylcholinesterase Acetylcholine Calcium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Wang J H

References (14)

14 references, click to expand

Studies on cholinesterase. VII. The active surface of acetylcholine esterase derived from effects of pH on inhibitors.
J Biol Chem. 1950 Aug;185(2):479-89 PMID: 14774389
Initiation and abolition of the action potential of a single node of Ranvier.
J Gen Physiol. 1956 Jan 20;39(3):377-95 PMID: 13286456
Changes in fluorescence, turbidity, and birefringence associated with nerve excitation.
Proc Natl Acad Sci U S A. 1968 Nov;61(3):883-8 PMID: 4301149
Evidence for structural changes during the action potential in nerves from the walking legs of Maia squinado.
J Physiol. 1968 Feb;194(2):85-6P PMID: 4295705
Role of surface dipoles on axon membrane.
Science. 1969 Jan 17;163(3864):280-2 PMID: 5762605
Light scattering and birefringence changes during nerve activity.
Nature. 1968 May 4;218(5140):438-41 PMID: 5649693
Chemistry of the active site of rhodopsin.
Biochem J. 1969 Nov;115(3):607-8 PMID: 5353533
Transient changes in extrinsic fluorescence of nerve produced by electric stimulation.
Proc Natl Acad Sci U S A. 1969 Dec;64(4):1362-8 PMID: 5271758
Electromagnetic emission at micron wavelengths from active nerves.
Biophys J. 1968 Jun;8(6):731-4 PMID: 5699805
On the localization of acetylcholine receptors.
J Physiol. 1955 Apr 28;128(1):157-81 PMID: 14368581
Chromophore transfer from lipid to protein in bovine rhodopsin.
Biochemistry. 1970 Apr 14;9(8):1817-20 PMID: 5439040
On the biochemical mechanism of the visual process.
Exp Eye Res. 1967 Oct;6(4):400-13 PMID: 6060552
Ionic movements and electrical activity in giant nerve fibres.
Proc R Soc Lond B Biol Sci. 1958 Jan 1;148(930):1-37 PMID: 13494473
On the cooperativity of biological membranes.
Proc Natl Acad Sci U S A. 1967 Feb;57(2):335-41 PMID: 16591474

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.67.2.916

Published

1970-10-00

Pages

916-20

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC283292

Subset

External Links

PubMed source DOI: 10.1073/pnas.67.2.916 PMC Full Text View journal details

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A possible role of phospholipid in nerve excitation.

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