Specific inhibition of mammalian ribonucleic acid C-type virus deoxyribonucleic acid polymerases by rat antisera.

Journal of virology ·Vol. 8 ·No. 5 ·1971-11-00 ·Pages 816-8

Oroszlan S, Hatanaka M, Gilden RV, Huebner RJ

Abstract

Inhibition of the ribonucleic acid (RNA)- and deoxyribonucleic acid (DNA)-dependent DNA polymerase activities of mammalian C-type viruses was obtained with sera from rats bearing murine leukemia virus-induced transplant tumors. Polymerase activities of nonmammalian (viper) C-type virus and murine mammary tumor virus were not inhibited by such sera nor by serum from a rat immunized with the DNA polymerase of feline leukemia virus purified by isoelectric focusing. The latter serum appeared to inhibit preferentially the DNA-dependent DNA polymerase activity of mammalian C-type viruses showing no inhibition of RNA-dependent DNA synthesis.

MeSH Terms

Animals Antigens, Viral Cats Cricetinae DNA Nucleotidyltransferases/isolation & purification Immune Sera Isoelectric Focusing Leukemia, Experimental/blood Mammary Tumor Virus, Mouse/enzymology,immunology Mice Oncogenic Viruses/enzymology,immunology Rats Retroviridae/enzymology,immunology Snakes

Chemicals

Antigens, Viral Immune Sera DNA Nucleotidyltransferases

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Oroszlan S

Hatanaka M

Gilden R V

Huebner R J

References (8)

8 references, click to expand

RNA-dependent DNA polymerase in virions of RNA tumour viruses.
Nature. 1970 Jun 27;226(5252):1209-11 PMID: 4316300
RNA-dependent DNA polymerase in virions of Rous sarcoma virus.
Nature. 1970 Jun 27;226(5252):1211-3 PMID: 4316301
DNA polymerase activity associated with RNA tumor viruses.
Proc Natl Acad Sci U S A. 1970 Sep;67(1):143-7 PMID: 4318773
DNA polymerase in defective Rous sarcoma virus.
Virology. 1971 May;44(2):457-62 PMID: 4327720
Species-specific and interspecific antigenic determinants associated with the structural protein of feline C-type virus.
Proc Natl Acad Sci U S A. 1971 May;68(5):901-4 PMID: 4102562
Antibody to the RNA-dependent DNA polymerase of mammalian C-type RNA tumor viruses.
Proc Natl Acad Sci U S A. 1971 May;68(5):920-4 PMID: 4325004
Separation of murine cellular and murine leukaemia virus DNA polymerases.
Nat New Biol. 1971 Jun 9;231(23):163-7 PMID: 5281193
Proteins of the murine C-type RNA tumour viruses: isolation of a group-specific antigen by isoelectric focusing.
J Gen Virol. 1970 Jul;8(1):1-10 PMID: 4990526

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.8.5.816-818.1971

Published

1971-11-00

Pages

816-8

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC376267

Subset

External Links

PubMed source DOI: 10.1128/JVI.8.5.816-818.1971 PMC Full Text View journal details

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Specific inhibition of mammalian ribonucleic acid C-type virus deoxyribonucleic acid polymerases by rat antisera.

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