Biological study of a nontoxic, water-soluble immunoadjuvant from mycobacterial cell walls.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 4 ·1972-04-00 ·Pages 855-8

Chedid L, Parant M, Parant F, Gustafson RH, Berger FM

Abstract

Whole mycobacterial cells, which are used in Freund's complete adjuvant, besides inducing hypersensitivity to tuberculoprotein, also can elicit hyperreactivity to endotoxins, lymphoid hyperplasia, and allergic polyarthritis in rats. The data reported here demonstrate that a potent water-soluble adjuvant obtained from mycobacterial cell walls is also effective in increasing the immune response to viruses, and that it is free of the toxic effects observed with whole mycobacterial cells.

MeSH Terms

Adjuvants, Immunologic/pharmacology Animals Antibody Formation/drug effects Antigen-Antibody Complex Arthritis/etiology,immunology Cell Wall/immunology Encephalomyocarditis virus Endotoxins Freund's Adjuvant Guinea Pigs Hepatomegaly/immunology Hypersensitivity, Delayed/immunology Male Mice Mice, Inbred Strains Mycobacterium/immunology Orthomyxoviridae Ovalbumin Precipitins Rats Splenomegaly/immunology Tuberculin

Chemicals

Adjuvants, Immunologic Antigen-Antibody Complex Endotoxins Precipitins Tuberculin Ovalbumin Freund's Adjuvant

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Chedid L

Parant M

Parant F

Gustafson R H

Berger F M

References (12)

12 references, click to expand

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THE AGGLUTINATION OF RED CELLS BY ALLANTOIC FLUID OF CHICK EMBRYOS INFECTED WITH INFLUENZA VIRUS.
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[Increase of the toxic power of killed Eberthella typhosa in rats inoculated with living BCG; relation between this increase of susceptibility and the functional state of the reticuloendothelial system].
C R Seances Soc Biol Fil. 1958;152(6):899-902 PMID: 13609074
Effects of Freund's adjuvant on adenovirus oncogenesis and antibody production in hamsters.
Int J Cancer. 1967 Sep 15;2(5):539-43 PMID: 6081596
Seventeen years' experience with mineral oil adjuvant influenza virus vaccines.
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Sensitivity of mice to endotoxin after vaccination with BCG (Bacillus Calmette-Guérin).
Proc Soc Exp Biol Med. 1958 Oct;99(1):167-9 PMID: 13601802
Granuloma formation induced in mice by chemically defined mycobacterial fractions.
J Bacteriol. 1969 Oct;100(1):95-102 PMID: 4981067
[Role of the macrophages in nonspecific immunity].
Ann Inst Pasteur (Paris). 1971 Mar;120(3):412-27 PMID: 4397154
Isolation and properties of a macromolecular, water-soluble, immuno-adjuvant fraction from the cell wall of Mycobacterium smegmatis.
Proc Natl Acad Sci U S A. 1972 Apr;69(4):851-4 PMID: 4502937
Immunotherapy of cancer: regression of tumors after intralesional injection of living Mycobacterium bovis.
Science. 1971 Apr 16;172(3980):271-3 PMID: 4323415
Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen.
J Immunol. 1960 Oct;85:403-17 PMID: 13782608
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.69.4.855

Published

1972-04-00

Pages

855-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC426580

Subset

External Links

PubMed source DOI: 10.1073/pnas.69.4.855 PMC Full Text View journal details

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Biological study of a nontoxic, water-soluble immunoadjuvant from mycobacterial cell walls.

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