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PMID: 4338595 Published · ppublish English Journal Article

Correlation of messenger RNA function with adenylate-rich segments in the genomes of single-stranded RNA viruses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 6 ·1972-06-00 ·Pages 1514-6

Johnston RE, Bose HR

Abstract

Oligonucleotides enriched in adenylate residues have been demonstrated in the genomes of two positive-strand RNA viruses, Sindbis and Columbia SK. Such oligonucleotides were not found in the genome of vesicular stomatitis virus, a negative-strand virus. The adenylate-rich oligonucleotides from Sindbis and Columbia SK viruses appeared similar when analyzed by zonal sedimentation in sucrose-sodium dodecyl sulfate.

MeSH Terms
Adenine Nucleotides/metabolism,physiology Centrifugation, Density Gradient Coliphages/enzymology Encephalomyocarditis virus/metabolism,physiology Genotype Pancreas/enzymology Polynucleotides/metabolism,physiology RNA Viruses/physiology RNA, Messenger/metabolism,physiology RNA, Viral/metabolism,physiology Ribonucleases Sindbis Virus/metabolism,physiology Vesicular stomatitis Indiana virus/metabolism,physiology
Chemicals
Adenine Nucleotides Polynucleotides RNA, Messenger RNA, Viral Ribonucleases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Johnston R E
Bose H R
References (15)
15 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.69.6.1514
Published
1972-06-00
Pages
1514-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC426738
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.69.6.1514 PMC Full Text View journal details
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