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PMID: 4338640 Published · ppublish English Journal Article

Genome homology of vesicular stomatitis virus and defective T particles and evidence for the sequential transcription of the virion ribonucleic acid.

Journal of virology ·Vol. 9 ·No. 6 ·1972-06-00 ·Pages 946-55

Roy P, Bishop DH

Abstract

The small defective T particle of vesicular stomatitis virus (VSV-111) has no detectable enzyme activity when assayed at 31 C, although qualitatively it possesses all the virion proteins found in complete VSV-1 virions. With VSV-1 transcription product ribonucleic acid (RNA), it is shown that the VSV-111 RNA is identical to part of the VSV-1 genome. Evidence is also presented to support the idea that in vitro VSV-1 transcription is sequential.

MeSH Terms
Animals Cell Line Centrifugation, Density Gradient Cricetinae Defective Viruses/analysis,enzymology,metabolism Electrophoresis, Disc Genetic Code Genetics, Microbial Kidney Phosphorus Isotopes RNA Nucleotidyltransferases/metabolism RNA, Viral/analysis,biosynthesis Ribonucleases Tritium Uracil Nucleotides/metabolism Uridine/metabolism Vesicular stomatitis Indiana virus/analysis,enzymology,isolation & purification,metabolism Viral Interference Virus Cultivation
Chemicals
Phosphorus Isotopes RNA, Viral Uracil Nucleotides Tritium RNA Nucleotidyltransferases Ribonucleases Uridine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Roy P
Bishop D H
References (20)
20 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.9.6.946-955.1972
Published
1972-06-00
Pages
946-55
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC356400
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.9.6.946-955.1972 PMC Full Text View journal details
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