Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

Science (New York, N.Y.) ·Vol. 177 ·No. 4050 ·1972-08-25 ·Pages 705-6

Sidwell RW, Huffman JH, Khare GP, Allen LB, Witkowski JT, Robins RK

Abstract

Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. Injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by Friend leukemia virus and respiratory infections caused by influenza A(O), A(2), and B viruses and parainfluenza 1 virus. infections is also effective.

MeSH Terms

Adenoviridae/drug effects Amides/pharmacology Animals Antiviral Agents Cells, Cultured Cytomegalovirus/drug effects DNA Viruses/drug effects Friend murine leukemia virus/drug effects Mice Microbial Sensitivity Tests Nucleosides/pharmacology Orthomyxoviridae/drug effects Poliovirus/drug effects RNA Viruses/drug effects Rabbits Rabies virus/drug effects Respirovirus/drug effects Rhinovirus/drug effects Ribonucleosides/pharmacology,therapeutic use Semliki forest virus/drug effects Triazoles/pharmacology Vaccinia virus/drug effects Vesicular stomatitis Indiana virus/drug effects Virus Diseases/drug therapy

Chemicals

Amides Antiviral Agents Nucleosides Ribonucleosides Triazoles

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Sidwell R W

Huffman J H

Khare G P

Allen L B

Witkowski J T

Robins R K

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.177.4050.705

Published

1972-08-25

Pages

705-6

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.177.4050.705 View journal details

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Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

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