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PMID: 4342239 Published · ppublish English Journal Article

Studies of the mechanism of enhancement of human adenovirus infection in monkey cells by simian virus 40.

Journal of virology ·Vol. 10 ·No. 2 ·1972-08-00 ·Pages 211-9

Baum SG, Horwitz MS, Maizel JV

Abstract

The defect which prevents human adenovirus replication in monkey cells and the mechanism whereby this restriction is overcome by coinfection with simian virus 40 (SV40) have been studied. Adenovirus capsid proteins are not synthesized efficiently in monkey cells in the absence of SV40. Adenovirus "enhancement" by SV40 was found to be the product of increased efficiency of replication by a small percentage of cells. This enhancement effect apparently occurred only when SV40 and adenovirus infected the same cells. These findings suggest that the replicative block occurs prior to virion assembly, and an accompanying report seeks to locate the site of restriction more precisely at the post-transcriptional level.

MeSH Terms
Adenoviridae/growth & development,metabolism Animals Carbon Isotopes Cell Line/microbiology Cells, Cultured/metabolism,microbiology Chromatography, DEAE-Cellulose Cytopathogenic Effect, Viral Electrophoresis, Polyacrylamide Gel Fluorescent Antibody Technique Haplorhini Humans Immunodiffusion Kidney Leucine/metabolism Peptides/analysis Serotyping Simian virus 40/growth & development Threonine/metabolism Transcription, Genetic Tritium Valine/metabolism Viral Proteins/analysis,biosynthesis,isolation & purification Virus Replication
Chemicals
Carbon Isotopes Peptides Viral Proteins Tritium Threonine Leucine Valine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Baum S G
Horwitz M S
Maizel J V
References (22)
22 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.10.2.211-219.1972
Published
1972-08-00
Pages
211-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC356452
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.10.2.211-219.1972 PMC Full Text View journal details
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