Amino acid neurotransmitter candidates: sodium-dependent high-affinity uptake by unique synaptosomal fractions.

Science (New York, N.Y.) ·Vol. 178 ·No. 4064 ·1972-12-01 ·Pages 997-9

Bennett JP, Logan WJ, Snyder SH

Abstract

Glutamic and aspartic acids and glycine are accumulated by high-affinity uptake systems into synaptosomal preparations in central nervous tissue. Sodium is required by these high-affinity transports, but not by the low-affinity transports for these and other amino acids. The sodium-requiring amino acid uptake systems label unique synaptosomal fractions. Observations suggest that these amino acids serve specific synaptic functions, presumably as neurotransmitters.

MeSH Terms

Amino Acids/metabolism Animals Arginine/metabolism Aspartic Acid/metabolism Carbon Isotopes Cerebral Cortex/metabolism Glutamates/metabolism Glycine/metabolism Leucine/metabolism Male Nerve Endings/metabolism Rats Sodium/pharmacology Spinal Cord/metabolism Synaptic Transmission Synaptic Vesicles/metabolism Synaptosomes/metabolism Tritium

Chemicals

Amino Acids Carbon Isotopes Glutamates Tritium Aspartic Acid Arginine Sodium Leucine Glycine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bennett J P

Logan W J

Snyder S H

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.178.4064.997

Published

1972-12-01

Pages

997-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.178.4064.997 View journal details

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Amino acid neurotransmitter candidates: sodium-dependent high-affinity uptake by unique synaptosomal fractions.

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