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PMID: 4347968 Published · ppublish English Journal Article

Metabolism of adenosine 3',5'-cyclic monophosphate and induction of fruiting bodies in Coprinus macrorhizus.

Journal of bacteriology ·Vol. 113 ·No. 3 ·1973-03-00 ·Pages 1249-55

Uno I, Ishikawa T

Abstract

The adenyl cyclase and phosphodiesterase metabolizing adenosine 3',5'-cyclic monophosphate (cyclic AMP) were detected in mycelia of strains of Coprinus macrorhizus which form fruiting bodies, but not in those of strains which do not form fruiting bodies. The adenyl cyclase synthesized cyclic AMP from adenosine triphosphate. The phosphodiesterase degr[UNK]ded cyclic AMP to adenosine-5'-monophosphate and was inhibited by adenosine-3'-monophosphate, theophylline, and caffeine. The strains which form fruiting bodies incorporated and metabolized cyclic AMP, but strains which do not form fruiting bodies did not. The possible participation of cyclic AMP in the induction of fruiting bodies is discussed.

MeSH Terms
Adenosine Monophosphate/biosynthesis,pharmacology Adenosine Triphosphate/metabolism Adenylyl Cyclases/metabolism Basidiomycota/enzymology,growth & development,metabolism Caffeine/pharmacology Cell-Free System Chromatography, Gel Chromatography, Ion Exchange Cyclic AMP/biosynthesis,metabolism Phosphodiesterase Inhibitors Phosphoric Diester Hydrolases/metabolism Spores, Fungal/growth & development Theophylline/pharmacology Tritium
Chemicals
Phosphodiesterase Inhibitors Tritium Caffeine Adenosine Monophosphate Adenosine Triphosphate Theophylline Cyclic AMP Phosphoric Diester Hydrolases Adenylyl Cyclases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Uno I
Ishikawa T
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20 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.113.3.1249-1255.1973
Published
1973-03-00
Pages
1249-55
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC251690
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.113.3.1249-1255.1973 PMC Full Text View journal details
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