Abstract
The mechanism by which excess quantities of bile salts in the colon produce diarrhea is not known. Therefore, experiments were performed in which the effect of conjugated dihydroxy bile salts on ion transport was evaluated in the in vitro short-circuited rat colon. 2 mM glycochenodeoxycholic acid (GCDC), taurochenodeoxycholic acid (TCDC), or taurodeoxycholic acid caused a prompt increase in short-circuit current (I(sc)) and electrical potential difference (PD). Similar results were obtained when theophylline was added. Removal of HCO(2) and C1 prevented the effects of both bile salts and theophylline. Pretreatment with theophylline blocked the increase in I(sc) and PD produced by TCDC and pretreatment with either TCDC or GCDC inhibited the expected theophylline response. Na fluxes in the presence of both TCDC and theophylline demonstrated a decrease in net absorption; and TCDC decreased net C1 absorption and theophylline caused a reversal of net C1 absorption to net C1 secretion. It is proposed that the diarrhea associated with cholerheic enteropathy is produced by active anion secretion possibly mediated by cyclic AMP.
MeSH Terms
Animals
Bicarbonates/pharmacology
Bile Acids and Salts/pharmacology
Biological Transport, Active/drug effects
Chenodeoxycholic Acid/antagonists & inhibitors,pharmacology
Chlorides/metabolism,pharmacology
Chlorine
Colon/drug effects,metabolism
Cyclic AMP/physiology
Diarrhea/etiology
Glycocholic Acid/pharmacology
Male
Membrane Potentials/drug effects
Radioisotopes
Rats
Sodium/metabolism
Sodium Isotopes
Taurocholic Acid/antagonists & inhibitors,pharmacology
Theophylline/antagonists & inhibitors,pharmacology
Chemicals
Bicarbonates
Bile Acids and Salts
Chlorides
Radioisotopes
Sodium Isotopes
Chenodeoxycholic Acid
Chlorine
Taurocholic Acid
Sodium
Theophylline
Cyclic AMP
Glycocholic Acid
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Binder H J
Rawlins C L
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25 references, click to expand
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