The mechanism of polymyxin B action and selectivity toward biologic membranes.

Chromatography, Thin Layer Dose-Response Relationship, Drug Drug Stability Erythrocytes/drug effects,metabolism Escherichia coli Glucose/metabolism Humans Hydrogen-Ion Concentration Liposomes Membranes/drug effects Methylation Models, Chemical Phosphatidylcholines Phosphatidylethanolamines Phospholipids/blood Polymyxins/administration & dosage,toxicity Structure-Activity Relationship

Liposomes Phosphatidylcholines Phosphatidylethanolamines Phospholipids Polymyxins Glucose