Interaction of lymphoid and nonlymphoid cells with the lymphocytosis-promoting factor of Bordetella pertussis.

Infection and immunity ·Vol. 7 ·No. 3 ·1973-03-00 ·Pages 461-7

Adler A, Morse SI

Abstract

The activity of soluble lymphocytosis-promoting factor (LPF) from Bordetella pertussis decreased after brief in vitro incubation with lymphoid cells or erythrocytes. The LPF activity was found to be associated with the cells used, and injection of the cells produced a leukocytosis and lymphocytosis which completely accounted for the loss of soluble activity. Attachment of LPF to cells was found to be reversible in vitro. It is suggested that reversible binding occurs in vivo.

MeSH Terms

Absorption Animals Bordetella pertussis/immunology Erythrocytes/immunology Female Leukocyte Count Leukocytosis Lymphocytes/immunology Lymphocytosis Mice Spleen/cytology,immunology

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Adler A

Morse S I

References (8)

8 references, click to expand

Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. I. Radioautographic analysis of the circulating cells in mice undergoing pertussis-induced hyperleukocytosis.
J Exp Med. 1967 Mar 1;125(3):401-8 PMID: 4289293
Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. II. The effect of pertussis vaccine on the thoracic duct lymph and lymphocytes of mice.
J Exp Med. 1967 Apr 1;125(4):619-28 PMID: 4289740
The occurrence and properties of leukocytosis and lymphocytosis-stimulating material in the supernatant fluids of Bordetella pertussis cultures.
J Exp Med. 1969 Mar 1;129(3):523-50 PMID: 4304138
Effects of the lymphocytosis-promoting factor from Bordetella pertussis on the function and potentiality of lymphocytes. I. Effect on the ability of lymphocytes to recirculate in the body.
Jpn J Med Sci Biol. 1970 Feb;23(1):47-60 PMID: 4317540
A preliminary report on the neutralization of the lymphocytosis-promoting factor (LPF) with anti-LPF serum.
Jpn J Med Sci Biol. 1970 Feb;23(1):67-70 PMID: 5310995
Studies on lymphocytes 18. Mechanism of lymphocytosis induced by supernatant fluids of Bordetella pertussis cultures.
Blood. 1971 Jul;38(1):49-59 PMID: 4326837
STUDIES ON THE LYMPHOCYTOSIS INDUCED IN MICE BY BORDETELLA PERTUSSIS.
J Exp Med. 1965 Jan 1;121:49-68 PMID: 14253487
Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. 3. The distribution of transfused lymphocytes in pertussis-treated and normal mice.
J Exp Med. 1970 Oct 1;132(4):663-72 PMID: 4323778

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.7.3.461-467.1973

Published

1973-03-00

Pages

461-7

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422700

Subset

External Links

PubMed source DOI: 10.1128/iai.7.3.461-467.1973 PMC Full Text View journal details

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Interaction of lymphoid and nonlymphoid cells with the lymphocytosis-promoting factor of Bordetella pertussis.

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