Leukocytosis-promoting factor of Bordetella pertussis. II. Biological properties.
The leukocytosis-promoting factor (LPF), purified from materials extracted from agar in which Bordetella pertussis was grown, caused leukocytosis and an increased sensitivity to histamine when as little as 0.04 mug of protein was given intravenously to mice. LPF was adsorbed onto erythrocytes, causing hemagglutination. As little as 0.03 mug of LPF protein agglutinated chicken erythrocytes in 0.05 ml of a 0.5% suspension. The physicochemical, biological, and immunological properties indicated that leukocytosis, increased sensitivity to histamine in mice, and agglutination of erythrocytes are functions of a single substance.
18 references, click to expand
-
Lymphocytosis and histamine sensitization of mice by fractions from Bordetella pertussis.J Bacteriol. 1968 Nov;96(5):1484-7 PMID: 4302297
-
Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. 3. The distribution of transfused lymphocytes in pertussis-treated and normal mice.J Exp Med. 1970 Oct 1;132(4):663-72 PMID: 4323778
-
The occurrence and properties of leukocytosis and lymphocytosis-stimulating material in the supernatant fluids of Bordetella pertussis cultures.J Exp Med. 1969 Mar 1;129(3):523-50 PMID: 4304138
-
Effect of lymphocytosis-promoting factor of Bordetella pertussis on the immune response. II. Adjuvant effect for the production of reaginic antibody in the rat.Int Arch Allergy Appl Immunol. 1972;43(2):207-16 PMID: 4342866
-
Effects of the lymphocytosis-promoting factor from Bordetella pertussis on the function and potentiality of lymphocytes. I. Effect on the ability of lymphocytes to recirculate in the body.Jpn J Med Sci Biol. 1970 Feb;23(1):47-60 PMID: 4317540
-
Protective antigen of haemophilus pertussis.Lancet. 1954 Jun 19;266(6825):1257-60 PMID: 13164367
-
Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. I. Radioautographic analysis of the circulating cells in mice undergoing pertussis-induced hyperleukocytosis.J Exp Med. 1967 Mar 1;125(3):401-8 PMID: 4289293
-
The hemagglutinin of Haemophilus pertussis. II. Observations on the structure of the hemagglutinating complex of culture supernatants.Aust J Exp Biol Med Sci. 1950 Sep;28(5):509-16 PMID: 14820695
-
The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.Arch Biochem Biophys. 1963 Jan;100:119-30 PMID: 14028302
-
A simple method for the quantitation of submicrogram amounts of bacterial endotoxin.Proc Soc Exp Biol Med. 1970 Mar;133(3):790-4 PMID: 5435570
-
Studies on the hemagglutinin of Hemophilus pertussis.J Immunol. 1950 Dec;65(6):627-32 PMID: 14803714
-
Leucocytosis-promoting factor of Bordetella pertussis. I. Purification and characterization.Infect Immun. 1972 Dec;6(6):899-904 PMID: 4344632
-
Production, extraction and purification of haemagglutinin of Haemophilus pertussis.J Gen Microbiol. 1952 Nov;7(3-4):201-10 PMID: 13022907
-
Histamine-sensitizing factors from microbial agents, with special reference to Bordetella pertussis.Bacteriol Rev. 1968 Jun;32(2):103-26 PMID: 4298544
-
Influence of Bordetella pertussis on Adenosine Diphosphate-Induced Aggregation of Mouse Platelets.Infect Immun. 1970 Sep;2(3):260-7 PMID: 16557829
-
Effect of lymphocytosis-promoting factor of Bordetella pertussis on the immune response. I. Suppression of cellular hypersensitivity reactions.Int Arch Allergy Appl Immunol. 1972;43(2):196-206 PMID: 4342865
-
Studies on the ultrastructure of Bordetella pertussis. I. Morphology, origin, and biological activity of structures present in the extracellular fluid of liquid cultures of Bordetella pertussis.J Exp Med. 1970 Jun 1;131(6):1342-57 PMID: 4315895
-
Adsorption of protective antigen of Hemophilus pertussis on human red cell stromata.Proc Soc Exp Biol Med. 1950 Dec;75(3):704-5 PMID: 14808372
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
