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PMID: 4353318 Published · ppublish English Journal Article

Barbiturate-induced transmitter release at a frog neuromuscular junction.

British journal of pharmacology ·Vol. 48 ·No. 1 ·1973-05-00 ·Pages 48-58

Thomson TD, Turkanis SA

Abstract

1. The influence of barbiturates on neuromuscular transmission at end-plates of frog sartorius muscles was investigated electrophysiologically on preparations bathed in Ringer solution containing a low concentration of calcium and a high concentration of magnesium.2. Effects of a convulsant barbiturate, 5-(2-cyclohexylideneëthyl)-5-ethyl barbituric acid (CHEB), were compared with those of phenobarbitone.3. CHEB and phenobarbitone increased the mean quantum content of the end-plate potentials and decreased the mean amplitude of the miniature end-plate potentials.4. Both barbiturates enhanced the duration of the nerve-terminal action potential and had little or no effect on the effective resistance of the skeletal muscle membrane.

MeSH Terms
Action Potentials/drug effects Animals Anura Barbiturates/pharmacology Electric Stimulation In Vitro Techniques Membrane Potentials/drug effects Microelectrodes Muscles/drug effects Nerve Endings/drug effects Neuromuscular Junction/drug effects Phenobarbital/pharmacology Rana pipiens Synaptic Transmission Time Factors
Chemicals
Barbiturates Phenobarbital
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Thomson T D
Turkanis S A
References (19)
19 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1973.tb08221.x
Published
1973-05-00
Pages
48-58
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1776099
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1973.tb08221.x PMC Full Text View journal details
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