Mechanism of activation of a cyclic adenosine 3':5'-monophosphate phosphodiesterase from bovine heart by calcium ions. Identification of the protein activator as a Ca2+ binding protein.

Acetates Ammonium Sulfate Animals Binding Sites Calcium Calcium Isotopes Cations, Divalent Cattle Centrifugation Chelating Agents Chromatography, DEAE-Cellulose Cyclic AMP Dialysis Drug Synergism Enzyme Activation Glycols Muscle Proteins/analysis,isolation & purification Myocardium/analysis,enzymology Osmolar Concentration Phosphodiesterase Inhibitors Phosphoric Diester Hydrolases Protein Binding

Acetates Calcium Isotopes Cations, Divalent Chelating Agents Glycols Muscle Proteins Phosphodiesterase Inhibitors Cyclic AMP Phosphoric Diester Hydrolases Ammonium Sulfate Calcium