Regulation of phosphodiesterase synthesis: requirement for cyclic adenosine monophosphate-dependent protein kinase.

Science (New York, N.Y.) ·Vol. 181 ·No. 4103 ·1973-09-07 ·Pages 952-4

Bourne HR, Tomkins GM, Dion S

Abstract

Endogenous cyclic adenosine monophosphate (AMP) and its dibutyryl derivative increase cyclic AMP phosphodiesterase activity in cultured lymphoma cells. This effect is prevented by cycloheximide. A variant population of cells deficient in cyclic AMP-dependent protein kinase contains lower basal phosphodiesterase activity, which cannot be induced by cyclic AMP.

MeSH Terms

Animals Butyrates Cell Line Cyclic AMP/metabolism,pharmacology Cycloheximide/pharmacology Dactinomycin/pharmacology Enzyme Induction/drug effects Feedback Isoproterenol/pharmacology Lymphoma Mice Phosphoric Diester Hydrolases/biosynthesis Phosphotransferases/metabolism Protein Kinases/metabolism

Chemicals

Butyrates Dactinomycin Cycloheximide Cyclic AMP Phosphotransferases Protein Kinases Phosphoric Diester Hydrolases Isoproterenol

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bourne H R

Tomkins G M

Dion S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.181.4103.952

Published

1973-09-07

Pages

952-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.181.4103.952 View journal details

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Regulation of phosphodiesterase synthesis: requirement for cyclic adenosine monophosphate-dependent protein kinase.

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