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PMID: 4357865 Published · ppublish English Journal Article

Homology between type-C viruses of various species as determined by molecular hybridization.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 12 ·1973-12-00 ·Pages 3316-20

Benveniste RE, Todaro GJ

Abstract

Two strains of feline leukemia virus, two endogenous feline type-C viruses (RD/CCC group), several endogenous and laboratory strains of murine "leukemia" virus, two rat viruses, two primate viruses (woolly monkey and gibbon ape), as well as hamster, pig, and avian type-C viruses were examined for their relatedness to one another by molecular hybridization. The extent of nucleic-acid homology was determined by hybridization of the various viral RNAs to a [(3)H]DNA product synthesized from each virus. Among the murine type-C viruses (Rauscher, Kirsten, AT-124, and endogenous BALB/c virus) a high degree of homology is observed, although the viruses are not identical. The two primate viruses are also closely related to one another. The feline, rat, hamster, and pig endogenous viruses can be readily distinguished from one another and from the murine and primate viruses since their DNA products share very little or no nucleic-acid homology. However, the murine and primate type-C virus groups possess a surprising degree of relatedness. Feline type-C viruses fall into two distinct groups, the feline leukemia virus group and the RD-114/CCC group, with little detectable nucleic-acid homology between them. Infection of feline or rat cells with type-C virus results in production of the endogenous type-C virus of the species along with the infecting virus.

MeSH Terms
Animals Avian Leukosis Virus/classification Cats Chickens Cricetinae DNA, Single-Stranded/metabolism DNA, Viral/analysis,metabolism Hominidae Leukemia Virus, Feline/classification Leukemia Virus, Murine/classification Mice Nucleic Acid Hybridization Oncogenic Viruses/classification RNA Viruses/classification RNA, Viral/metabolism Rabbits Rats Rauscher Virus/classification Retroviridae/classification Simian virus 40/classification Swine Tritium
Chemicals
DNA, Single-Stranded DNA, Viral RNA, Viral Tritium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Benveniste R E
Todaro G J
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35 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.70.12.3316
Published
1973-12-00
Pages
3316-20
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC427227
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.70.12.3316 PMC Full Text View journal details
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