Identification of a distinction between cytoplasmic histone synthesis and subsequent histone deposition within the nucleus.

Animals Carcinoma, Hepatocellular/metabolism Cell Division Cell Fractionation Cell Nucleus/drug effects,metabolism Cells, Cultured Chromosomes/metabolism Cytoplasm/metabolism DNA/pharmacology Electrophoresis, Polyacrylamide Gel Histones/biosynthesis,isolation & purification,metabolism Liver/cytology,metabolism Liver Neoplasms/metabolism Lysine/metabolism Membranes/metabolism Mice Neoplasms, Experimental/metabolism Phosphates/metabolism Protein Binding Rats Tritium

Histones Phosphates Tritium DNA Lysine