Characterization of poliovirus isolates in Japan after the mass vaccination with live oral poliomyelitis vaccine (Sabin).
From 1962 to 1968, 127 poliovirus isolates (92 from clinical specimens and 35 from healthy subjects) were subjected to intratypic serodifferentiation by the modified Wecker and McBride techniques. The two techniques gave concordant results for 103 strains, 91 of which were classified as vaccine-like, 9 as nonvaccine-like, and 3 as intermediate; 20 were classified as vaccine-like by one technique and as intermediate by the other, and 4 as nonvaccine-like by one technique and as intermediate by the other. The origin of the nonvaccine-like strains is unknown, but it is unlikely that they had been circulating in the community long. An rct/40-marker test of the isolates revealed a higher positivity rate than that found in field trials of Sabin vaccine. The results indicate that wild poliovirus has been almost completely eradicated from Japan.
14 references, click to expand
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Serodifferentiation of type 3 poliovirus strains isolated 1960-1965 from patients and healthy vaccinees. Characterization of strains associated with disease in vaccinated persons and household contacts.Am J Epidemiol. 1968 Mar;87(2):396-410 PMID: 4296727
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Antigenic characterization of poliovirus strains by neutralization kinetic studies and the modified Wecker technique.Jpn J Med Sci Biol. 1969 Aug;22(4):217-33 PMID: 4311583
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Antigenic segregation of type 2 poliovirus isolants related and unrelated to Sabin's vaccine strain with modified Wecker technique.Am J Epidemiol. 1970 Mar;91(3):317-27 PMID: 4313253
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Antigenic characterization of poliovirus strains isolated in Italy (1964-1968) from vaccinated and unvaccinated patients.Ann Inst Pasteur (Paris). 1970 Feb;118(2):224-34 PMID: 4313585
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The stability of the intratypic antigenic character of Sabin's type 1 attenuated virus (LSc-2ab).Arch Gesamte Virusforsch. 1962;12:7-16 PMID: 13926717
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THE USE OF A MODIFIED WECKER TECHNIQUE FOR SERODIFFERENTIATION OF TYPE 1 POLIOVIRUSES RELATED AND UNRELATED TO SABIN'S VACCINE STRAIN. II. ANTIGENIC SEGREGATION OF ISOLATES FROM SPECIMENS COLLECTED IN FIELD STUDIES.Am J Hyg. 1963 Sep;78:214-26 PMID: 14063724
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