Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

Abetalipoproteinemia/metabolism Alcohol Oxidoreductases/metabolism Carbon Radioisotopes Cells, Cultured Child Cholesterol/biosynthesis,pharmacology Chromatography, Thin Layer Cycloheximide/pharmacology Fibroblasts/drug effects,enzymology Glutarates Homozygote Humans Hyperlipidemias/enzymology,genetics Infant, Newborn Insulin/pharmacology Lipoproteins, HDL/pharmacology Lipoproteins, LDL/pharmacology Lipoproteins, VLDL/pharmacology Male Mevalonic Acid Skin/enzymology Tritium

Carbon Radioisotopes Glutarates Insulin Lipoproteins, HDL Lipoproteins, LDL Lipoproteins, VLDL Tritium Cholesterol Cycloheximide Alcohol Oxidoreductases Mevalonic Acid