DNA of Epstein-Barr virus detected in tissue of Burkitt's lymphoma and nasopharyngeal carcinoma.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 11 ·1973-11-00 ·Pages 3265-8

Nonoyama M, Huang CH, Pagano JS, Klein G, Singh S

Abstract

The association of Epstein-Barr virus (EBV) DNA with African tumors was examined by the method of hybridization with complementary RNA. 22 out of 23 biopsies of Burkitt's lymphoma and 18 out of 23 biopsies of nasopharyngeal carcinoma were found to contain EBV DNA. The number of EBV genome equivalents per cell ranged from four to 113. Five out of 24 other African tumors, two adenocarcinomas, and one each of melanoma, reticulum cell sarcoma, and carcinoma of the antrum, also contained EBV DNA.

MeSH Terms

Adenocarcinoma/microbiology Africa Antibodies, Viral/analysis Burkitt Lymphoma/immunology,microbiology Carcinoma/immunology,microbiology Carcinoma, Squamous Cell/microbiology Carotid Body Tumor/microbiology DNA, Viral/isolation & purification,metabolism Female Herpesvirus 4, Human Humans Jaw Neoplasms/microbiology Lymphoma, Large B-Cell, Diffuse/microbiology Lymphoma, Non-Hodgkin/microbiology Male Maxillary Sinus Melanoma/microbiology Nasopharyngeal Neoplasms/immunology,microbiology Nucleic Acid Hybridization RNA, Viral/metabolism

Chemicals

Antibodies, Viral DNA, Viral RNA, Viral

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Nonoyama M

Huang C H

Pagano J S

Klein G

Singh S

References (9)

9 references, click to expand

EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx.
Nature. 1970 Dec 12;228(5276):1056-8 PMID: 4320657
Detection of Epstein-Barr viral genome in nonproductive cells.
Nat New Biol. 1971 Sep 22;233(38):103-6 PMID: 4328798
Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus-infected cells.
Int J Cancer. 1971 Sep 15;8(2):272-82 PMID: 4332368
EB-virus associated serology in malignant disease: antibody levels to viral capsid antigens (VCA), membrane antigens (MA) and early antigens(EA) in patients with various neoplastic conditions.
Int J Cancer. 1972 Mar 15;9(2):353-64 PMID: 4339412
Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis.
N Engl J Med. 1973 Feb 1;288(5):229-32 PMID: 4345064
Homology between Epstein-Barr virus DNA and viral DNA from Burkitt's lymphoma and nasopharyngeal carcinoma determined by DNA-DNA reassociation kinetics.
Nature. 1973 Mar 2;242(5392):44-7 PMID: 4348458
Selective thrombocytopenia due to localised microangiopathy of renal allografts.
Lancet. 1973 Nov 3;302(7836):988-91 PMID: 4127277
VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA.
Lancet. 1964 Mar 28;1(7335):702-3 PMID: 14107961
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.
Biochem J. 1956 Feb;62(2):315-23 PMID: 13293190

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.70.11.3265

Published

1973-11-00

Pages

3265-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC427213

Subset

External Links

PubMed source DOI: 10.1073/pnas.70.11.3265 PMC Full Text View journal details

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DNA of Epstein-Barr virus detected in tissue of Burkitt's lymphoma and nasopharyngeal carcinoma.

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