Picrotoxin antagonism of gamma-aminobutyric acid inhibitory responses and synaptic inhibition in the rat substantia nigra.

British journal of pharmacology ·Vol. 49 ·No. 4 ·1973-12-00 ·Pages 696-8

Crossman AR, Walker RJ, Woodruff GN

Abstract

Neurones in the substantia nigra of the rat, anaesthetized with urethane, are inhibited both by electrical stimulation of the ipsilateral caudate nucleus and by iontophoretically applied gamma-aminobutyric acid (GABA). Iontophoretically applied picrotoxin reversibly blocks both of these inhibitory responses. These results are consistent with the hypothesis that GABA is the transmitter released by the inhibitory striato-nigral pathway.

MeSH Terms

Aminobutyrates/antagonists & inhibitors Animals Electric Stimulation Female Iontophoresis Microelectrodes Oscillometry Picrotoxin/pharmacology Rats Substantia Nigra/drug effects Synapses/drug effects Synaptic Transmission/drug effects

Chemicals

Aminobutyrates Picrotoxin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Crossman A R

Walker R J

Woodruff G N

References (9)

9 references, click to expand

Micromethods in neuropharmacology: an approach to the study of anesthetics.
Anesthesiology. 1967 Jan-Feb;28(1):54-64 PMID: 6017441
Electrophysiological analysis of reciprocal caudato-nigral relations.
Brain Res. 1967 Nov;6(3):440-56 PMID: 6076250
Regional distribution of gamma-aminobutyric acid (GABA) in brain of the rhesus monkey.
J Neurochem. 1968 Mar;15(3):209-13 PMID: 4966292
Monosynaptic inhibition of neurons of the substantia nigra by caudato-nigral fibers.
Brain Res. 1971 Sep 10;32(1):225-8 PMID: 4329651
Blockage of caudate-evoked inhibition of neurons in the substantia nigra by picrotoxin.
Brain Res. 1971 Sep 10;32(1):229-33 PMID: 4329652
Role of -aminobutyric acid (GABA) in the extrapyramidal motor system. 1. Regional distribution of GABA in rabbit, rat, guinea pig and baboon CNS.
Exp Brain Res. 1971 Nov 30;13(5):514-8 PMID: 5137301
-aminobutyric acid and a caudato-nigral inhibition.
Can J Physiol Pharmacol. 1971 Dec;49(12):1113-5 PMID: 5142317
The distribution of glutamic decarboxylase in the nervous system of the rhesus monkey.
J Biol Chem. 1959 Apr;234(4):926-8 PMID: 13654292
Distribution of glutamic acid decarboxylase activity in human brain.
J Neurochem. 1962 Jul-Aug;9:399-401 PMID: 14476935

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1973.tb08546.x

Published

1973-12-00

Pages

696-8

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1776601

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1973.tb08546.x PMC Full Text View journal details

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Picrotoxin antagonism of gamma-aminobutyric acid inhibitory responses and synaptic inhibition in the rat substantia nigra.

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