Inhibition of macromolecular synthesis in Escherichia coli by protease inhibitors. Specific reversal by glutathione of the effects of chloromethyl ketones.

Alkanesulfonates/pharmacology Amidines/pharmacology Bacterial Proteins/biosynthesis Carbon Radioisotopes Chlorine/pharmacology Enzyme Induction/drug effects Escherichia coli/drug effects,enzymology,metabolism Galactosidases/biosynthesis Glutathione/metabolism,pharmacology Glycine/pharmacology Iodoacetates/pharmacology Lysine/pharmacology Peptide Hydrolases/metabolism Phenyl Ethers/pharmacology Phenylalanine/pharmacology Protease Inhibitors RNA, Bacterial/biosynthesis Ribonucleases/antagonists & inhibitors,metabolism Structure-Activity Relationship Sulfhydryl Compounds/antagonists & inhibitors Tosyl Compounds/pharmacology

Alkanesulfonates Amidines Bacterial Proteins Carbon Radioisotopes Iodoacetates Phenyl Ethers Protease Inhibitors RNA, Bacterial Sulfhydryl Compounds Tosyl Compounds Phenylalanine Chlorine Ribonucleases Galactosidases Peptide Hydrolases Glutathione Lysine Glycine