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PMID: 4365375 Published · ppublish English Journal Article

A cell-contact model for cellular position determination in development.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 8 ·1973-08-00 ·Pages 2396-400

McMahon D

Abstract

The fate of a cell in a developing organism is a function of its position within the organism. The molecular mechanism that cells use to determine their position and to convert positional information into a form that can be used to regulate the expression of genes is not understood. This paper presents a model in which contacts between complementary molecules on plasma membranes of adjacent cells regulate the concentration of a morphogenetic substance and transmit positional information. This model is described by four equations that, when solved with realistic parameters, demonstrated that this mechanism will produce discrete populations of cells within a few hours from an initially undifferentiated array of cells. The model suggests an explanation for several phenomena that have been observed and suggests experiments to test it and to clearly differentiate it from other models for position determination.

MeSH Terms
Amoeba Animals Cell Aggregation Cell Differentiation Cell Movement Cyclic AMP/metabolism Models, Biological
Chemicals
Cyclic AMP
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
McMahon D
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42 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.70.8.2396
Published
1973-08-00
Pages
2396-400
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC433743
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.70.8.2396 PMC Full Text View journal details
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