Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina.

Science (New York, N.Y.) ·Vol. 186 ·No. 4162 ·1974-11-01 ·Pages 449-51

Farber DB, Lolley RN

Abstract

As a result of an early deficiency in cyclic nucleotide phosphodiesterase activity, guanosine 3',5'-monophosphate accumulates in retinal photoreceptor cells before they begin to degenerate. It is suggested that degeneration of the photoreceptor cells is related to an imbalance in their metabolism or function which is caused by the elevated levels of cyclic guanosine monophosphate.

MeSH Terms

Adenylyl Cyclases/metabolism Animals Animals, Newborn/growth & development,metabolism Chromatography, Ion Exchange Chromosome Aberrations/metabolism Chromosome Disorders Cyclic AMP/metabolism Cyclic GMP/metabolism Mice Mice, Inbred C3H/growth & development,metabolism Mice, Inbred DBA/metabolism Nerve Degeneration Phosphoric Diester Hydrolases/metabolism Photoreceptor Cells/enzymology,growth & development,metabolism Protein Binding Retina/abnormalities,enzymology,growth & development,innervation,metabolism Time Factors

Chemicals

Cyclic AMP Phosphoric Diester Hydrolases Adenylyl Cyclases Cyclic GMP

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Farber D B

Lolley R N

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.186.4162.449

Published

1974-11-01

Pages

449-51

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.186.4162.449 View journal details

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Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina.

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