Increased collagen synthesis in blood vessels of hypertensive rats and its reversal by antihypertensive agents.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 8 ·1974-08-00 ·Pages 3019-23

Ooshima A, Fuller GC, Cardinale GJ, Spector S, Udenfriend S

Abstract

Collagen synthesis is increased in the aortas, mesenteric arteries, and to a lesser extent, in the hearts of rats either made hypertensive with desoxycorticosterone acetate-salt or that are spontaneously hypertensive. Several markers of collagen biosynthesis were shown to be increased, including prolyl hydroxylase (EC 1.14.11.2; proline, 2-oxoglutarate dioxygenase), prolyl hydroxylase-related antigen, total collagen content, and the incorporation of [(3)H]proline into total protein and into collagen. The antihypertensive agents chlorothiazide and reserpine, when administered before the onset of hypertension in the rats treated with desoxycorticosterone acetate-salt, prevented or diminished the increase in collagen biosynthesis. When reserpine was given after the onset of hypertension, prolyl hydroxylase activity was decreased concomitant with the decrease in blood pressure. Treatment with reserpine is particularly effective in diminishing arterial prolyl hydroxylase activity.

MeSH Terms

Animals Aorta/metabolism Blood Pressure/drug effects Chlorothiazide/pharmacology Collagen/biosynthesis,metabolism Depression, Chemical Desoxycorticosterone Hypertension/chemically induced,enzymology,metabolism Male Mesenteric Arteries/metabolism Myocardium/metabolism Procollagen-Proline Dioxygenase/metabolism Proline/metabolism Rats Reserpine/pharmacology Stimulation, Chemical Tritium

Chemicals

Tritium Desoxycorticosterone Chlorothiazide Reserpine Collagen Proline Procollagen-Proline Dioxygenase

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Ooshima A

Fuller G C

Cardinale G J

Spector S

Udenfriend S

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23 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.71.8.3019

Published

1974-08-00

Pages

3019-23

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388611

Subset

External Links

PubMed source DOI: 10.1073/pnas.71.8.3019 PMC Full Text View journal details

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Increased collagen synthesis in blood vessels of hypertensive rats and its reversal by antihypertensive agents.

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