N-(phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture.

Animals Aspartate Carbamoyltransferase/antagonists & inhibitors Aspartic Acid/analogs & derivatives,pharmacology Bicarbonates Carbamates Carbon Radioisotopes Cell Division/drug effects Cell Line Cell Transformation, Neoplastic Cells, Cultured Chromatography, Ion Exchange Fibroblasts Haplorhini Kidney Kinetics Mice Mice, Inbred Strains Organophosphonates/pharmacology Organophosphorus Compounds Phosphonoacetic Acid/analogs & derivatives Simian virus 40 Species Specificity Time Factors Tritium Uridine/pharmacology

Bicarbonates Carbamates Carbon Radioisotopes Organophosphonates Organophosphorus Compounds Tritium Aspartic Acid sparfosic acid Aspartate Carbamoyltransferase Phosphonoacetic Acid Uridine