Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis.

Infection and immunity ·Vol. 10 ·No. 4 ·1974-10-00 ·Pages 688-94

Norrby E, Link H, Olsson JE, Panelius M, Salmi A, Vandvik B

Abstract

The occurrence of a local production in the central nervous system (CNS) of antibodies against different selected viruses was analyzed by comparison of titers in serum and cerebrospinal fluid samples from groups of 50 patients with multiple sclerosis from Finland, Norway, and Sweden. Measles antibodies were determined in hemagglutination inhibition, hemolysis inhibition, and nucleocapsid complement fixation tests; mumps, parainfluenza virus type 1, and rubella virus antibodies were determined in hemagglutination inhibition tests; and herpes simplex virus type 1 antibodies were determined in passive hemagglutination tests. For reference purposes tests were also made for adenovirus antibodies in penton hemagglutination enhancement tests and poliovirus antibodies in neutralization enhancement tests. Among the 150 multiple sclerosis patients, a local production of antibodies against measles virus was found in the CNS in 57%, against rubella virus in 19%, mumps virus in 15%, herpes simplex virus type 1 in 11%, and parainfluenza virus type 1 (Sendai) in 3%. A local production in the CNS of antibodies against any of the viruses studied was found in 71% of multiple sclerosis patients. These included 48, 16, and 7% that produced antibodies to one, two, and three or more viruses, respectively.

MeSH Terms

Adenoviridae/immunology Adult Antibodies, Viral/analysis,cerebrospinal fluid Female Finland Humans Male Measles virus/immunology Middle Aged Multiple Sclerosis/immunology Mumps virus/immunology Norway Poliovirus/immunology Respirovirus/immunology Rubella virus/immunology Simplexvirus/immunology Sweden

Chemicals

Antibodies, Viral

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Norrby E

Link H

Olsson J E

Panelius M

Salmi A

Vandvik B

References (21)

21 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.10.4.688-694.1974

Published

1974-10-00

Pages

688-94

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC423007

Subset

External Links

PubMed source DOI: 10.1128/iai.10.4.688-694.1974 PMC Full Text View journal details

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Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis.

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