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PMID: 4375470 Published · ppublish English Journal Article

Regulation of hepatic lipogenesis by plasma free fatty acids: simultaneous studies on lipoprotein secretion, cholesterol synthesis, ketogenesis and gluconeogenesis.

The Biochemical journal ·Vol. 140 ·No. 1 ·1974-04-00 ·Pages 111-4

Mayes PA, Topping DL

Abstract

1. An inverse logarithmic relationship was found between lipogenesis and the concentration of serum free fatty acids perfusing the rat liver. 2. Increased concentrations of serum free fatty acids did not alter cholesterol synthesis, triglyceride secretion or increase gluconeogenesis. 3. No direct relationship was found between ketogenesis and either lipogenesis or gluconeogenesis.

MeSH Terms
Animals Cholesterol/biosynthesis Fatty Acids/biosynthesis Fatty Acids, Nonesterified/blood,pharmacology Gluconeogenesis/drug effects Ketone Bodies/biosynthesis Lipids/biosynthesis Lipoproteins/biosynthesis Lipoproteins, VLDL/biosynthesis Liver/drug effects,metabolism Male Rats Triglycerides/biosynthesis
Chemicals
Fatty Acids Fatty Acids, Nonesterified Ketone Bodies Lipids Lipoproteins Lipoproteins, VLDL Triglycerides Cholesterol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mayes P A
Topping D L
References (20)
20 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1400111
Published
1974-04-00
Pages
111-4
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1167977
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1400111 PMC Full Text View journal details
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