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PMID: 4376146 Published · ppublish English Journal Article

Effect of cyclic guanosine 3,5-monophosphate on the synthesis of enzymes sensitive to caatabolite repression in intact cells of Escherichia coli.

Journal of bacteriology ·Vol. 120 ·No. 2 ·1974-11-00 ·Pages 980-3

Artman M, Werthamer S

Abstract

Cyclic guanosine 3',5'-monophosphate inhibits the synthesis of beta-galactosidase and tryptophanase in cultures of Escherichia coli growing in minimal media with glucose or glycerol as the carbon source. Cyclic guanosine 3',5'-monophosphate acts at the transcriptional level in the lac operon, it exerts its action at the promoter site of the operon, and requires the presence of functional cyclic adenosine 3',5'-monophosphate receptor protein.

MeSH Terms
Carbon Radioisotopes Culture Media Cyclic AMP/pharmacology Cyclic GMP/pharmacology Enzyme Induction Escherichia coli/drug effects,enzymology Galactosidases/antagonists & inhibitors,biosynthesis Glucose/pharmacology Glycerol/pharmacology Leucine/metabolism Lyases/biosynthesis Mutation Nucleic Acid Hybridization RNA, Messenger/metabolism Stimulation, Chemical Tryptophanase/antagonists & inhibitors,biosynthesis
Chemicals
Carbon Radioisotopes Culture Media RNA, Messenger Cyclic AMP Galactosidases Lyases Tryptophanase Leucine Cyclic GMP Glucose Glycerol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Artman M
Werthamer S
References (19)
19 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.120.2.980-983.1974
Published
1974-11-00
Pages
980-3
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC245867
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.120.2.980-983.1974 PMC Full Text View journal details
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