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PMID: 4377003 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Increased polyamine concentrations in the cerebrospinal fluid of patients with brain tumors.

International journal of cancer ·Vol. 14 ·No. 6 ·1974-12-15 ·Pages 731-5

Marton LJ, Heby O, Wilson CB

Abstract

An automated method for the quantitative analysis of the polyamines putrescine, spermidine and spermine in cerebrospinal fluid (CSF) was used to analyze CSF samples from 37 patients with central nervous system (CNS) tumors and from 13 patients without tumors. The putrescine and spermidine concentrations in the CSF of most patients in tumors, particularly those with glioblastomas or medulloblastomas, were elevated when compared with those of non-tumor-bearing patients.

MeSH Terms
Adenoma, Acidophil/cerebrospinal fluid Adenoma, Chromophobe/cerebrospinal fluid Adolescent Adult Aged Astrocytoma/cerebrospinal fluid Brain Neoplasms/cerebrospinal fluid Cerebellar Neoplasms/cerebrospinal fluid Child Child, Preschool Cholesteatoma/cerebrospinal fluid Ependymoma/cerebrospinal fluid Female Glioblastoma/cerebrospinal fluid Humans Male Medulloblastoma/cerebrospinal fluid Meningioma/cerebrospinal fluid Middle Aged Neurilemmoma/cerebrospinal fluid Pituitary Neoplasms/cerebrospinal fluid Putrescine/cerebrospinal fluid Spermidine/cerebrospinal fluid Spermine/cerebrospinal fluid Teratoma/cerebrospinal fluid
Chemicals
Spermine Spermidine Putrescine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Marton L J
Heby O
Wilson C B
Article Info
Journal
International journal of cancer
Abbr.
Int J Cancer
ISSN
0020-7136
DOI
10.1002/ijc.2910140606
Published
1974-12-15
Pages
731-5
Language
English
Region
United States
NLM ID
0042124
Subset
IM
External Links
PubMed source DOI: 10.1002/ijc.2910140606 View journal details
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