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PMID: 4380397 Published · ppublish English Journal Article

The influences of andrenotropic drugs and noradrenaline on the histamine release in cardiac anaphylaxis in vitro.

The Journal of physiology ·Vol. 184 ·No. 4 ·1966-06-00 ·Pages 924-41

Giotti A, Guidotti A, Mannaioni PF, Zilletti L

Abstract

1. The regional distribution (auricles, ventricles and septum) of histamine and its release during anaphylaxis were studied in isolated perfused guinea-pig hearts.2. The highest value of histamine content was found in the right auricle, the lowest in the left ventricle and septum, both in normal hearts, and in the hearts subjected to anaphylaxis.3. The fraction of the total histamine released in the course of 24 min by antigen was 50%. The fraction released from the different regions of the heart was similar. No evidence was found for release of 5-hydroxytryptamine.4. A relation was found between the distribution of mast cells and the tissue concentration of histamine. The highest number of mast cells per unit area was found in the right auricle; the lowest in the left ventricle.5. The histamine release by antigen was reduced by previous treatment with (+)-tubocurarine; the histamine release by (+)-tubocurarine was depressed by previous challenge of the heart with antigen.6. Reserpine reduces histamine release. Perfusion of reserpine-treated hearts with noradrenaline partially restored histamine release.7. beta-Adrenergic blocking agents (dichloroisoproterenol and pronethalol) reduced histamine release.8. The drugs tested did not modify the tissue concentration of histamine.9. The possibility of a modulating activity of catecholamines on histamine release in cardiac anaphylaxis is discussed.

MeSH Terms
Anaphylaxis/physiopathology Animals Antigens Catecholamines Ethanolamines/pharmacology Female Guinea Pigs Heart/physiopathology Histamine/analysis In Vitro Techniques Isoproterenol/pharmacology Male Mast Cells Norepinephrine/pharmacology Perfusion Reserpine/pharmacology Tubocurarine/pharmacology
Chemicals
Antigens Catecholamines Ethanolamines Histamine Reserpine Isoproterenol Tubocurarine Norepinephrine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Giotti A
Guidotti A
Mannaioni P F
Zilletti L
References (30)
30 references, click to expand
  1. Evidence that induced histamine is an intrinsic regulator of the microcirculatory system.
    Am J Physiol. 1962 Jan;202:66-72 PMID: 14498094
  2. Effect of antigen and octylamine on mast cells and histamine content of sensitized guinea-pig tissues.
    J Physiol. 1959 Oct;147:425-36 PMID: 14424651
  3. [Anaphylaxis in the heart isolated according to the Langendorff method and treated with reserpine and bretylium].
    Boll Soc Ital Biol Sper. 1961 Nov 30;37:1140-4 PMID: 14469349
  4. THE EFFECTS OF DRUGS ON THE UPTAKE OF AMINES BY MAST CELLS.
    Br J Pharmacol Chemother. 1964 Oct;23:405-19 PMID: 14228141
  5. [Acetylcholine in myocardium. IV. Effect of vagal stimulation of the acetylcholine content of rat and guinea pig hearts].
    Pflugers Arch. 1955;261(1):24-31 PMID: 13254281
  6. [The concentration of noradrenalin and adrenalin in isolated sections of the heart].
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1959;237:350-64 PMID: 14425481
  7. A sensitive method for the assay of 5-hydroxytryptamine.
    Br J Pharmacol Chemother. 1957 Sep;12(3):344-9 PMID: 13460242
  8. Liberation of histamine by adrenaline from isolated lung.
    Arch Int Pharmacodyn Ther. 1950 Jan;81(1):91-8 PMID: 15408633
  9. A comparison of the effects of anaphylactic shock and of chemical histamine releasers.
    J Physiol. 1952 Dec;118(4):461-78 PMID: 13023644
  10. The effects of reserpine and compound 48/80 on the release of amines from the mast cells of rats.
    Br J Pharmacol Chemother. 1956 Dec;11(4):411-6 PMID: 13383119
  11. The subcellular distribution of histamine, slow-reacting substance and 5-hydroxytryptamine in the brain of the rat.
    Br J Pharmacol Chemother. 1963 Apr;20:264-77 PMID: 14018677
  12. Histamine release by adrenaline and D-tubocurarine in the human subject.
    J Physiol. 1953 Apr 28;120(1-2):146-54 PMID: 13062228
  13. A method of estimating histamine in plasma.
    Br J Pharmacol Chemother. 1957 Dec;12(4):397-405 PMID: 13489164
  14. [Decrease in tissue and blood histamine by the action of reserpine].
    Boll Soc Ital Biol Sper. 1961 Dec 31;37:1478-81 PMID: 13933049
  15. Bioassays and mathematics.
    Pharmacol Rev. 1953 Mar;5(1):87-134 PMID: 13046989
  16. Quantitative adsorption of antibody by the isolated heart and the intensity of cardiac anaphylaxis.
    Circ Res. 1961 Jan;9:177-83 PMID: 13698619
  17. Action of compound 48/80 on the mast cells and histamine content of guinea-pig tissues.
    Br J Pharmacol Chemother. 1956 Sep;11(3):304-7 PMID: 13364205
  18. EFFECT OF CATECHOLAMINES ON THE RESPONSES OF THE NICTITATING MEMBRANE TO NERVOUS STIMULATION IN CATS TREATED WITH RESERPINE.
    J Physiol. 1963 Oct;168:804-19 PMID: 14072859
  19. Liberation of histamine by the heart muscle.
    J Physiol. 1936 May 4;86(4):431-51 PMID: 16994770
  20. Effect of catecholamines and their chloroanalogs on the in vitro release of histamine from cells of rat peritoneal fluid.
    Biochem Pharmacol. 1962 Oct;11:979-80 PMID: 13975384
  21. [Anaphylactic reactions in the isolated guinea pig auricle preparation and their influencing by antihistaminics. BOL, dihydroergotamine and reserpine].
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1959;236:421-34 PMID: 13829189
  22. A method of conducting a biological assay on a preparation giving repeated graded responses illustrated by the estimation of histamine.
    J Physiol. 1942 Jun 2;101(1):115-30 PMID: 16991544
  23. A method for the fluorometric assay of histamine in tissues.
    J Pharmacol Exp Ther. 1959 Nov;127:182-6 PMID: 14446178
  24. Histamine release and intracellular potentials during anaphylaxis in the isolated heart.
    Circ Res. 1960 Jul;8:713-23 PMID: 13821916
  25. Heart Autotransplantation: Effect on Myocardial Catecholamine and Histamine.
    Science. 1962 Oct 5;138(3536):40-1 PMID: 17790883
  26. The quantitative estimation of histamine in the blood.
    J Physiol. 1937 Apr 9;89(3):257-68 PMID: 16994858
  27. EFFECTS OF ADRENOTROPIC DRUGS ON THE RELEASE OF HISTAMINE IN THE ANAPHYLACTIC REACTION OF THE ISOLATED GUINEA PIG HEART.
    Life Sci. 1964 Apr;3:347-50 PMID: 14172949
  28. Studies on the relationship of 5-hydroxytryptamine and the enterochromaffin cell to anaphylactic shock in mice.
    J Exp Med. 1962 Feb 1;115:367-82 PMID: 13898067
  29. Factors influencing the urinary excretion of histamine in the rat.
    J Physiol. 1954 Oct 28;126(1):141-54 PMID: 13212736
  30. Release of histamine from skin and muscle in the cat by opium alkaloids and other histamine liberators.
    J Physiol. 1951 Aug;114(4):490-509 PMID: 14874225
Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1966.sp007957
Published
1966-06-00
Pages
924-41
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1357627
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1966.sp007957 PMC Full Text View journal details
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