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PMID: 4391049 Published · ppublish English Journal Article

Regulation of liver tyrosine aminotransferase by endogenous factors in the mouse.

The Journal of general physiology ·Vol. 54 ·No. 6 ·1969-12-00 ·Pages 675-89

Finch CE, Huberman HS, Mirsky AE

Abstract

The levels of mouse liver tyrosine aminotransferase (TAT) are shown to increase rapidly and transiently during and after various challenges (e.g., exposure to cold or shaking) to the homeostatic machinery of the fasted mouse. The increase of TAT is dependent on gene activity. Recent feeding and adrenalectomy are shown to inhibit the induction of TAT during the challenge of cold.

MeSH Terms
Adrenal Glands/physiology Adrenalectomy Animals Body Temperature Circadian Rhythm Cold Temperature Corticosterone/analysis DNA/analysis Dactinomycin/pharmacology Enzyme Induction Fasting Genes Injections, Intraperitoneal Insulin/pharmacology Liver/enzymology Male Mice Stress, Physiological Tyrosine Transaminase/antagonists & inhibitors,metabolism
Chemicals
Insulin Dactinomycin DNA Tyrosine Transaminase Corticosterone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Finch C E
Huberman H S
Mirsky A E
References (31)
31 references, click to expand
  1. Induction of tyrosine-alpha-ketoglutarate transaminase in rat liver. IV. Evidence for an increase in the rate of enzyme synthesis.
    J Biol Chem. 1962 Nov;237:3495-8 PMID: 14031971
  2. Template stability of some enzymes in rat liver and hepatoma.
    Proc Natl Acad Sci U S A. 1965 Sep;54(3):845-51 PMID: 4379377
  3. Regulation of the daily rhythm in tyrosine transaminase activity by environmental factors.
    Proc Natl Acad Sci U S A. 1968 Dec;61(4):1287-91 PMID: 5249810
  4. Systematic oscillations in tyrosine transaminase and other metabolic functions in liver of normal and adrenalectomized rats on controlled feeding schedules.
    J Nutr. 1968 Jun;95(2):207-27 PMID: 4385831
  5. Studies on the regulation of tyrosine aminotransferase in rats.
    J Biol Chem. 1967 Apr 10;242(7):1398-405 PMID: 4381533
  6. The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and homogentisic acid.
    Biochem J. 1951 Oct;49(5):686-93 PMID: 14886367
  7. The activation and induction of rat liver tryptophan pyrrolase in vivo by its substrate.
    J Biol Chem. 1961 Jan;236:158-61 PMID: 13708324
  8. Relationships between hepatic enzyme induction, glutamate formation, and purine nucleotide biosynthesis in glucocorticoid action.
    J Biol Chem. 1966 Dec 25;241(24):5819-26 PMID: 4380931
  9. The effect of alimentary factors on liver glycogen rhythm and the distribution of glycogen in the liver lobule.
    Anat Rec. 1949 Jun;104(2):189-216 PMID: 18134499
  10. ACTINOMYCIN D AND MESSENGER-RNA TURNOVER.
    Nature. 1964 Sep 12;203:1134-6 PMID: 14213658
  11. Early estrogen action: concomitant stimulations within two minutes of nuclear RNA synthesis and uptake of RNA precursor by the uterus.
    Proc Natl Acad Sci U S A. 1966 Nov;56(5):1594-8 PMID: 5230318
  12. The functional significance of changes in activity of the enzymes, tryptophan pyrrolase and tyrosine transaminase, after induction in intact rats and in the isolated, perfused rat liver.
    J Biol Chem. 1969 Mar 25;244(6):1410-6 PMID: 4388057
  13. Regulation of tyrosine-alpha-ketoglutarate transaminase in rat liver. VII. Hormonal effects of synthesis in the isolated, perfused liver.
    J Biol Chem. 1968 Jun 25;243(12):3296-300 PMID: 4385342
  14. GLUCOCORTICOIDS AND TRANSAMINASE ACTIVITY. VII. STUDIES ON THE NATURE AND SPECIFICITY OF SUBSTRATE INDUCTION OF TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASE AND TRYPTOPHAN PYRROLASE.
    J Biol Chem. 1963 Nov;238:3730-5 PMID: 14109212
  15. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.
    Biochem J. 1956 Feb;62(2):315-23 PMID: 13293190
  16. Regulation of tyrosine alpha-ketoglutarate transaminase in rat liver. VI. Induction by pancreatic hormones.
    J Biol Chem. 1967 Oct 10;242(19):4372-7 PMID: 6065084
  17. The identification of corticosterone in human plasma and its assay by isotope dilution.
    J Biol Chem. 1957 Mar;225(1):25-37 PMID: 13416215
  18. Daily rhythm of liver tyrosine transaminase and of plasma tyrosine and glucose after removal of the pancreas of rats.
    Life Sci. 1969 Jul 1;8(13):685-91 PMID: 4389888
  19. The effect of hydrocortisone on tyrosine-alpha-ketoglutarate transaminase and tryptophan pyrrolase activities in the isolated, perfused rat liver.
    J Biol Chem. 1962 May;237:1723-6 PMID: 13899904
  20. Circadian rhythms of liver enzymes and their relationship to enzyme induction.
    Science. 1967 Sep 29;157(3796):1563-4 PMID: 4382575
  21. Maturation of a stress-activated mechanism inhibiting induction of tyrosine transaminase.
    Science. 1966 Jun 17;152(3729):1642-3 PMID: 4379973
  22. Alterations in the nature of ribonucleic acid synthesized in rat liver during regeneration and after cortisol administration.
    J Biol Chem. 1967 Mar 10;242(5):801-8 PMID: 6020435
  23. A PARADOXICAL EFFECT OF ACTINOMYCIN D: THE MECHANISM OF REGULATION OF ENZYME SYNTHESIS BY HYDROCORTISONE.
    Proc Natl Acad Sci U S A. 1964 Oct;52:1121-9 PMID: 14224391
  24. Ageing and the regulation of cell activities during exposure to cold.
    J Gen Physiol. 1969 Dec;54(6):690-712 PMID: 4391050
  25. Transamination as a step in tyrosine metabolism.
    J Biol Chem. 1951 Nov;193(1):293-8 PMID: 14907716
  26. SELECTIVE ALTERATIONS OF MAMMALIAN MESSENGER-RNA SYNTHESIS: EVIDENCE FOR DIFFERENTIAL ACTION OF HORMONES ON GENE TRANSCRIPTION.
    Nature. 1964 Aug 8;203:599-603 PMID: 14250967
  27. Hormonal factors altering rhythmicity of tyrosine-alpha-ketoglutarate transaminase in rat liver.
    Endocrinology. 1967 Oct;81(4):811-8 PMID: 4382820
  28. Regulation of tyrosine alpha-ketoglutarate transaminase in rat liver. V. Repression in growth hormone-treated rats.
    J Biol Chem. 1967 Oct 10;242(19):4367-71 PMID: 6065083
  29. Adaptive response of tryptophan pyrrolase and tyrosine transaminase in rat liver after partial hepatectomy and laparotomy.
    Biochim Biophys Acta. 1968 Sep 3;165(2):218-24 PMID: 4386685
  30. Adaptation of the rat liver tyrosine-alpha-ketoglutarate transaminase.
    Biochim Biophys Acta. 1957 Oct;26(1):85-8 PMID: 13479464
  31. Induction of tyrosine-alpha-ketoglutarate transaminase in rat liver. I. Hormonal nature.
    J Biol Chem. 1961 Oct;236:2699-702 PMID: 14455202
Article Info
Journal
The Journal of general physiology
Abbr.
J Gen Physiol
ISSN
0022-1295
DOI
10.1085/jgp.54.6.675
Published
1969-12-00
Pages
675-89
Language
English
Region
United States
NLM ID
2985110R
PMCID
PMC2225954
Subset
IM
External Links
PubMed source DOI: 10.1085/jgp.54.6.675 PMC Full Text View journal details
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