Synergism of thymus and bone marrow in the production of gra a5hilgard HR: Synergism of thymus and bone marrow in the production of graft-versus-host splenomegaly in x-irradiated hosts.

The Journal of experimental medicine ·Vol. 132 ·No. 2 ·1970-08-01 ·Pages 317-28

Hilgard HR

Abstract

Graft-versus-host splenomegaly may be elicited from 500 R X-irradiated F(1) hybrid hosts if the hosts are injected with bone marrow cells and thymus cells from parental strain donors. Cells from thymus only or bone marrow only will not elicit graft-versus-host splenomegaly in these hosts. In this requirement for cells from both sources, the bone marrow cells play a nonimmunologic, proliferative role in the splenomegaly, and the thymus cells carry out the immunologic attack. Thus the mechanism of this synergism is quite different from that reported for the humoral immune response to sheep erythrocytes in which both thymus and marrow interact in the production of the specific immunologic response itself.

MeSH Terms

Animals Antibody Formation Antibody-Producing Cells Antigens Bone Marrow/physiopathology Bone Marrow Cells Bone Marrow Transplantation Erythrocytes/immunology Female Graft vs Host Reaction Hyperplasia Immunogenetics Lymphocyte Transfusion Lymphocytes/immunology Male Mice Mitosis Radiation Chimera Splenomegaly/etiology,physiopathology Thymus Gland/cytology

Chemicals

Antigens

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Hilgard H R

References (22)

22 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.132.2.317

Published

1970-08-01

Pages

317-28

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2138739

Subset

External Links

PubMed source DOI: 10.1084/jem.132.2.317 PMC Full Text View journal details

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Synergism of thymus and bone marrow in the production of gra a5hilgard HR: Synergism of thymus and bone marrow in the production of graft-versus-host splenomegaly in x-irradiated hosts.

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