Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates.

The Journal of experimental medicine ·Vol. 134 ·No. 1 ·1971-07-01 ·Pages 201-23

Katz DH, Davie JM, Paul WE, Benacerraf B

Abstract

Administration of nonimmunogenic 2,4-dinitrophenyl (DNP) conjugates of copolymers of D or L-glutamic acid and lysine (GL) induces hapten-specific tolerance in nonimmune and DNP-ovalbumin-primed strain 13 guinea pigs. This tolerant state is evidenced by depressed anti-DNP antibody synthesis in response to challenge with DNP-ovalbumin and by a diminished frequency of DNP-specific antigen-binding cells and of anti-DNP antibody-secreting cells. Such a nonimmunogenic compound (DNP-D-GL) will nevertheless elicit a DNP-specific anamnestic antibody response when administered at an appropriate time to DNP-ovalbumin-primed guinea pigs undergoing a graft-versus-host reaction. These experiments are discussed in terms of a two-cell theory of stimulation of antibody responses.

MeSH Terms

Animals Antibodies Antibody Formation Antibody Specificity Antibody-Producing Cells Autoradiography Bone Marrow/immunology Bone Marrow Cells Dinitrophenols Glutamates Graft vs Host Reaction Guinea Pigs Haptens Immune Tolerance Immunity, Cellular Immunization, Passive Iodine Isotopes Lysine Ovalbumin Thymus Gland/immunology

Chemicals

Antibodies Dinitrophenols Glutamates Haptens Iodine Isotopes Ovalbumin Lysine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Katz D H

Davie J M

Paul W E

Benacerraf B

References (34)

34 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.134.1.201

Published

1971-07-01

Pages

201-23

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139028

Subset

External Links

PubMed source DOI: 10.1084/jem.134.1.201 PMC Full Text View journal details

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Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates.

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