Inhibition of pyruvate and beta-hydroxybutyrate oxidation in rat brain mitochondria by phenylpyruvate and alpha-ketoisocaproate.

Animals Brain/cytology,drug effects,metabolism Caproates/pharmacology Cinnamates/pharmacology Cyanides/pharmacology Glutamates/metabolism Hydroxybutyrate Dehydrogenase/metabolism Hydroxybutyrates/metabolism Keto Acids/pharmacology Kinetics Malates/metabolism Male Mitochondria/drug effects,metabolism Oxidation-Reduction Oxidative Phosphorylation/drug effects Oxygen Consumption/drug effects Phenylpyruvic Acids/pharmacology Pyruvate Dehydrogenase Complex/metabolism Pyruvates Rats Succinates/metabolism

Caproates Cinnamates Cyanides Glutamates Hydroxybutyrates Keto Acids Malates Phenylpyruvic Acids Pyruvate Dehydrogenase Complex Pyruvates Succinates Hydroxybutyrate Dehydrogenase